The Takoradi Technical University was established in September, 2016, as a result of the government’s policy to convert Takoradi Polytechnic, among five other Polytechnics, to the status of Technical University. In effect, since April 1954, Takoradi Technical University (formerly Takoradi Polytechnic) has existed as a Government Technical Institute under the Ghana Education Service of the Ministry of Education.

During that period, the institute offered programmes mainly at the Craft and Technician Certificate levels in commercial and technical subjects, awarding Royal Society of Arts (RSA) and City and Guilds of London, United Kingdom. However, in 1990, the Ghana Education Service took over the awards of the above-mentioned certificates.